top of page
Search

Adjunctive brexpiprazole in patients with major depressive disorder and anxiety symptoms: post hoc a

  • Mark W. Wilson, MD
  • Feb 2, 2019
  • 2 min read

Michael E Thase, Emmanuelle Weiller, Peter Zhang, Catherine Weiss, Roger S McIntyre

Neuropsychiatric Disease and Treatment 2019, 15: 37-45

"Objective: Episodes of major depressive disorder (MDD) characterized by high levels of anxiety symptoms are less likely to respond to some forms of antidepressant treatment (ADT). This report examines the effects of adjunctive brexpiprazole on depressive symptoms among patients with MDD and anxiety symptoms.

Materials and methods: This was a post hoc analysis of 1,171 patients from the 6-week, randomized, double-blind phases of three studies in adults with MDD and inadequate response to ADTs (NCT01360645, NCT01360632, NCT02196506). Data were pooled for brexpiprazole 2-3 mg/day and for placebo (adjunct to ADT). Montgomery-Åsberg Depression Rating Scale Total score changes were assessed in subgroups of patients with and without anxious distress (based on proxies for the Diagnostic and Statistical Manual of Mental Disorders , Fifth Edition criteria) and anxious depression (defined as a Hamilton Depression Rating Scale Anxiety/somatization factor score of ≥7). Safety was assessed by the incidence of treatment-emergent adverse events (TEAEs).

Results: Benefits were seen for adjunctive brexpiprazole (compared with adjunctive placebo) in both anxiety definition subgroups. For patients with anxious distress, the least squares mean difference (95% CI) at week 6 was -3.00 (-4.29, -1.71; P <0.0001) and, for those without anxious distress, was -1.38 (-2.71, -0.05; P =0.043). For patients with anxious depression, the difference was -2.19 (-3.60, -0.78; P =0.0023), compared with -2.34 (-3.58, -1.10; P =0.0002) for those without anxious depression. The most common TEAEs among patients with anxiety symptoms receiving ADT + brexpiprazole were akathisia, headache, restlessness, somnolence, and weight increase. There were no clinically meaningful differences in the rates of these TEAEs according to the presence or absence of anxiety symptoms.

Conclusion: Adjunctive brexpiprazole 2-3 mg/day may be efficacious in reducing depressive symptoms, and was well tolerated, in patients with clinically relevant anxiety symptoms."

 
 
 

Recent Posts

See All
New Phone Numbers AND New Address

My NEW routine, non-emergency office number is now (917) 566-5798; the old number, (917) 441-2344, will no longer be used. My NEW...

 
 
 
April Vacation

I will be out of the country from April 9 – April 17, 2022. Please keep in mind the following: If you require refills while I am away,...

 
 
 
Single Post: Blog_Single_Post_Widget
  • You can send in payment in the following ways

    • You may use Zelle; it is linked to mark@markwwilsonmdpc.com; make sure you type TWO w’s, not one.

    • You may use PayPal; it is linked to markwwilsonmdpc/mark@markwwilsonmdpc.com; make sure you type TWO w’s, not one.

    • You can give my assistant credit card information.

    • You can send payment in by to my office address.

​

​

mark@markwwilsonmdpc.com

assistant@markwwilsonmdpc.com

office (917) 566-5798

emergency (917) 621-6615

​

​

©2018 by Mark W. Wilson, MD, PC. Proudly created with Wix.com

bottom of page